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Synergetic Antibacterial Tannic Acid/Bi-Enzyme-Based Coatings: Layer-by-Layer and One-Pot Films.

Fernanda Haga Kobiraki¹, Asma Riahi¹, Sarah Benmalek-Kehili¹

¹Université de Strasbourg, CNRS, Institut Charles Sadron UPR 22, Strasbourg 67034, France.

ACS Applied Bio Materials

|May 27, 2026

Summary

This study presents sustainable antibacterial coatings using tannic acid (TA) and enzymes to combat bacterial biofilms. The developed coatings effectively eradicate Staphylococcus aureus and inhibit biofilm formation through synergistic action.

Keywords:

H2O2 release amylase amyloglucosidase antibacterial coatings glucose oxidase polyethyleneimine tannic acid

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Area of Science:

Biomaterials Science
Antimicrobial Technology
Surface Chemistry

Background:

Bacterial biofilms pose significant threats in healthcare and industry, leading to infections and economic losses.
Developing effective and sustainable antibacterial strategies is crucial to mitigate these challenges.

Purpose of the Study:

To develop sustainable antibacterial coatings utilizing tannic acid (TA) and a combination of amyloglucosidase (AMG) and glucose oxidase (GOX) enzymes.
To investigate the efficacy of these coatings against Staphylococcus aureus (S. aureus) biofilms.

Main Methods:

Layer-by-layer (LbL) and one-pot deposition methods were employed to create TA/AMG-GOX films on polyethylene imine precursor layers.
The coatings leverage tannic acid's properties and hydrogen peroxide (H2O2) generated enzymatically from starch.

Main Results:

Complete eradication of planktonic and adherent S. aureus was achieved with both LbL and one-pot TA/AMG-GOX films.
Significant inhibition of S. aureus biofilm formation was observed (98% in starch-rich, 41% in starch-free environments).
Synergistic antibacterial action between released TA and enzymatically produced H2O2 was demonstrated.

Conclusions:

The developed TA/AMG-GOX coatings offer a potent and sustainable solution for combating S. aureus biofilms.
This enzymatic cascade approach provides a novel mechanism for antibacterial strategies, with potential for targeting biofilm matrix components.