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Updated: May 29, 2026
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
A novel ferritin-based nanoparticle vaccine targeting lgE confers protection against chronic allergic asthma in a
Wenjie Li1, Sha Liu1, Weiwei Cui1
1Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao 266073, China.
Background:
Allergic asthma is a major global health concern owing to its high prevalence and substantial socioeconomic burden. It is characterized by elevated levels of immunoglobulin E (IgE), which plays a pivotal role in the pathophysiology of allergic disorders. Therapeutic anti-IgE antibodies, including omalizumab, have emerged as a validated strategy for the management of IgE-mediated disorders. However, their clinical use requires repeated administration and remains costly. Here, we developed a nanoparticle-based anti-IgE vaccine by genetically fusing an IgE-derived epitope peptide to the N-terminus of a hybrid ferritin.
Results:
The antigen was expressed in E.coli and purified to homogeneity. Preventive vaccination was conducted in a mouse model of chronic allergic asthma. High levels of anti-IgE antibodies were elicited and ameliorated key features of allergic asthma including the reduction in IgE levels, peribronchiolar inflammation, mucus production, and altered expression of inflammation-related genes.
Conclusion:
The anti-IgE vaccine developed in this study has protective effects in allergic asthma mice, offering a promising translatable strategy for the prevention and treatment of chronic allergic asthma.
