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Related Experiment Video

Updated: May 29, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Chemical biology tools for studying tissue development.

Mingming Zhang¹, Shuo Han¹

¹Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Key Laboratory of RNA Innovation Science and Engineering, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Seminars in Cell & Developmental Biology

|May 27, 2026

Summary

This summary is machine-generated.

Chemical biology tools like fluorescent proteins and bioorthogonal probes enable real-time observation and manipulation of molecular and cellular processes. This aids in understanding development, regeneration, and aging, paving the way for new discoveries and therapies.

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Related Experiment Videos

Last Updated: May 29, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos

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Published on: October 12, 2017

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Area of Science:

Chemical Biology
Developmental Biology
Molecular Biology

Background:

Spatiotemporal dynamics of molecular and cellular processes are crucial for understanding development, regeneration, and aging.
Observing and perturbing these processes in real time is a significant challenge.

Purpose of the Study:

To review the application of chemical biology tools for observing and manipulating molecular and cellular processes.
To highlight how these tools aid in understanding development, regeneration, and aging.

Main Methods:

Genetically encoded fluorescent proteins
Bioorthogonal probes
Molecular labeling reactions
Synthetic signaling pathways

Main Results:

These tools enable high-resolution mapping and targeted manipulation of cell signaling, cell fates, and tissue microenvironments.
Applications span from decoding morphogen gradients in embryogenesis to targeting hallmarks of aging.

Conclusions:

Integrating chemical biology strategies offers a powerful approach to drive future discoveries.
This integration can lead to the invention of novel therapeutic strategies.