BCL2L10 Is a non-GCB-associated prognostic biomarker and functional driver in diffuse large B-Cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is characterized by marked heterogeneity between GCB and non-GCB subtypes. Here, we identified BCL2L10 as a non-GCB-specific oncogene through integrated bioinformatics, clinical validation, and functional assays. BCL2L10 was significantly upregulated in non-GCB DLBCL at both mRNA and protein levels. High BCL2L10 expression served as an independent adverse prognostic factor and correlated with advanced clinical stage. Gene set enrichment analysis linked BCL2L10 to biosynthetic and stress-response pathways. Functional assays demonstrated that BCL2L10 knockdown selectively suppressed proliferation in non-GCB DLBCL cells, whereas overexpression only mildly promoted GCB cell growth. Our findings identify BCL2L10 as a novel subtype-specific prognostic biomarker and therapeutic target for high-risk non-GCB DLBCL.