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Related Experiment Video

Updated: May 29, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Neuromodulation techniques for managing overactive bladder.

Eleonora Rosato1, Francesco Di Rocco1, Giorgio Cerrelli1

  • 1Faculty of Medicine and Surgery, University of Rome Tor Vergata, Via di Montpellier 1, 00133, Rome, Italy.

Autonomic Neuroscience : Basic & Clinical
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) treatment is challenging. Neuromodulation offers effective options like sacral neuromodulation, with AI potentially improving patient selection and outcomes for lower urinary tract dysfunction.

Keywords:
Lower urinary tract symptomsOveractive bladderPeroneal nerve stimulationPudendal nerve stimulationSacral neuromodulationTibial nerve stimulationTranscranial magnetic stimulation

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Last Updated: May 29, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
10:26

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

Area of Science:

  • Urology
  • Neuroscience
  • Medical Technology

Background:

  • Overactive bladder (OAB) significantly impacts patient quality of life (QoL).
  • OAB treatment is challenging due to complex pathophysiology and therapy resistance.
  • Neuromodulation is an emerging, minimally invasive strategy for OAB management.

Purpose of the Study:

  • To review current neuromodulation techniques for OAB.
  • To discuss the role of artificial intelligence (AI) in optimizing OAB treatment.
  • To explore AI's potential in precision medicine for lower urinary tract dysfunction.

Main Methods:

  • Review of current literature on neuromodulation for OAB.
  • Analysis of sacral nerve stimulation (SNS) as gold standard.
  • Evaluation of tibial nerve stimulation (TNS) as a second/third-line option.
  • Exploration of emerging techniques like pudendal and spinal cord stimulation.
  • Discussion on AI applications in patient selection and outcome prediction.

Main Results:

  • Sacral neuromodulation is the established gold standard for OAB, showing efficacy, safety, and QoL improvement.
  • Tibial nerve stimulation is a less invasive option for refractory OAB.
  • Pudendal and spinal cord stimulation are experimental but show promise in select cases.
  • AI holds potential for enhancing clinical decision-making in OAB neuromodulation.

Conclusions:

  • Neuromodulation techniques, particularly sacral neuromodulation, are vital for managing refractory OAB.
  • Predicting treatment response and selecting optimal techniques remain challenging.
  • Artificial intelligence offers a promising avenue for personalized OAB management and improved patient outcomes.