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Updated: May 29, 2026

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
07:08

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein

Published on: January 16, 2020

Farnesylation-driven KRAS phase separation promotes colon tumor growth

Xingwen Wang1, Yi Zhang1, Minqiao Lu1

  • 1School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China; Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology, HIT Zhengzhou Research Institute, Zhengzhou 450000, China.

Cell
|May 27, 2026
PubMed
Summary

Kirsten Rat Sarcoma viral oncogene homolog (KRAS) forms cytoplasmic condensates via liquid-liquid phase separation (LLPS), promoting colon cancer growth. Statins disrupt this process, offering a potential therapeutic strategy.

Keywords:
KRASRCE1colon cancerfarnesylationphase separation

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