Related Experiment Video
Updated: May 29, 2026
Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
Published on: May 31, 2022
From winter flounder to multifunctional applications: A review of pleurocidin-like peptides via visualization and
Zhihe Fu1, Sifei Yang1, Yixin Gao2
1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Background:
Pleurocidin is an antimicrobial peptide (AMP) derived from the winter flounder (Pleuronectes americanus), attracting significant attention due to its unique structure and potent bioactivities. However, systematic evaluation and visual analysis of the fundamental knowledge, current status, and trends in this field remain insufficient.
Methods:
This study employs data analysis and visualization techniques to systematically assess the research landscape of pleurocidin-like peptides, aiming to identify current hotspots and forecast future directions. We analyzed 111 relevant publications from the Web of Science Core Citation database (2005-2025) using tools including Scimago Graphica, VOSviewer, and CiteSpace. The quantitative evaluation encompassed annual publication trends, geographical and institutional distribution, collaboration networks, and keyword evolution.
Results:
China and the United States are identified as the most influential countries, with Kyungpook National University in South Korea as the central hub in the collaborative network. Current research on pleurocidin-like peptides focuses on their diverse biological activities, mechanisms of action, optimized design, and applications, with computer-aided molecular design emerging as a prominent new trend.
Conclusions:
Current research particularly highlights the biological activities of these peptides, along with their specific mechanisms. In addition, various innovative modification strategies have been proposed for optimizing pleurocidin-like peptides and enhancing their stability, efficacy, and biocompatibility. This work aims to establish a theoretical foundation for advancing the applications of pleurocidin-like peptides in aquaculture, food preservation, and the pharmaceutical industry.
