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Related Experiment Video

Updated: May 29, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

The Costs, Cost-Effectiveness, and Methods for Evaluating Clinical Registries: A Systematic Scoping Review.

Kalpa Pisavadia¹, Ned Hartfiel¹, Anne Krayer²

¹Center for Health Economics and Evaluation, School of Health Sciences, Bangor University, Bangor, Wales, UK.

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research

|May 27, 2026

Summary

Clinical registries are cost-effective digital health investments, offering significant returns on investment. Future research should standardize economic evaluations and include equity analyses for better comparability.

Keywords:

clinical registries cost-effectiveness costs economic evaluation health economics registry-based studies

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Last Updated: May 29, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Area of Science:

Health Informatics
Health Economics
Digital Health Systems

Background:

Clinical registries are vital for digital health infrastructure, supporting quality improvement and research.
The economic value and cost-effectiveness of clinical registries are not well understood.
This review synthesizes evidence on the costs, cost-effectiveness, and economic evaluation methods for clinical registries.

Purpose of the Study:

To systematically scope the evidence on the costs and cost-effectiveness of clinical registries.
To identify and evaluate methods used in economic evaluations of clinical registries.
To understand the economic value proposition of clinical registries in healthcare.

Main Methods:

Searched Medline, Embase, CINAHL, and Cochrane Library up to February 2025.
Included full economic evaluations, cost-only studies, and grey literature on registry costs.
Assessed methodological quality using CHEERS, JBI, and COI checklists.

Main Results:

Six economic evaluations showed registries were cost-effective or cost-saving, with ROI from 1.5 to over 2,250 per £1 invested.
Sixteen cost-only studies and grey literature detailed costs across registry types, revealing economies of scale.
Larger registries and national programs demonstrated greater efficiencies; equity analyses were infrequent.

Conclusions:

Clinical registries are strategic, cost-effective investments in digital health.
Economic benefits and efficiencies support continued national and international investment in registries.
Standardized costing methods and integrated equity analyses are recommended for future evaluations.