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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 29, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Targeting Arginine Metabolism to Reverse Immune Paralysis in Cancer.

Giulia Elizabeth Borsatti1, Francesca Cutruzzolà1, Sharon Spizzichino1

  • 1Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

Anticancer Research
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Tumors create arginine-poor environments, suppressing immune cells like T lymphocytes. Targeting arginine metabolism offers a promising strategy for cancer immunotherapy by restoring antitumor immunity.

Keywords:
Arginine metabolismT cell anergycancer immunoeditingimmunometabolismreviewtumor microenvironment

Related Experiment Videos

Last Updated: May 29, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Area of Science:

  • Immunology
  • Metabolic pathways
  • Cancer biology

Background:

  • The immune system, through surveillance and immunoediting, combats cancer but can also promote tumor escape.
  • Metabolic immune suppression is a key mechanism where tumors weaken immune function without causing cell death.
  • L-arginine availability is crucial for immune cell function and is actively depleted in the tumor microenvironment.

Purpose of the Study:

  • To review the current understanding of L-arginine-dependent immune suppression in cancer.
  • To explore the mechanisms by which tumors create arginine-poor niches.
  • To discuss therapeutic strategies targeting arginine metabolism for cancer immunotherapy.

Main Methods:

  • Review of existing literature on arginine metabolism and immune suppression.
  • Focus on arginase and nitric oxide synthase pathways.
  • Analysis of arginine transport competition and nutrient-sensing signaling (mTORC1, GCN2).

Main Results:

  • Tumors deplete L-arginine, leading to functional paralysis of immune cells, especially T lymphocytes.
  • This metabolic imbalance selectively suppresses antitumor immunity while tumor cells adapt.
  • Arginine depletion involves tumor cells and immunosuppressive myeloid/stromal populations expressing metabolizing enzymes.

Conclusions:

  • Arginine metabolism is a critical regulator of tumor-induced immune suppression.
  • Targeting arginine pathways can potentially restore antitumor immunity.
  • The arginine system represents a significant target for novel cancer immunotherapies.