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Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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Published on: October 25, 2024

Steroids as antibacterials.

Andrew Daab1, David M Beal1, Jamie Kemp1

  • 1School of Natural Sciences, University of Kent, Canterbury, United Kingdom.

Advances in Microbial Physiology
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Steroid compounds show promise as antibacterials, with fungal-derived fusidane steroids being particularly effective against various bacteria. This review consolidates research on their utility, potential, and challenges for future drug development.

Keywords:
AntibacterialCatabolismCholesterolFusidaneRepurposingSapogeninSteroid

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Area of Science:

  • Medicinal Chemistry
  • Microbiology
  • Pharmacology

Background:

  • The literature on steroid antibacterials is fragmented, despite early research.
  • Steroidal compounds have demonstrated antibacterial properties, yet few are clinically utilized.

Purpose of the Study:

  • To consolidate fragmented research on steroidal compounds as antibacterials.
  • To assess the utility, structural features, origins, toxicities, and metabolic pathways of steroid antibacterials.
  • To explore the potential of steroid antibacterials for future drug development and repurposing.

Main Methods:

  • Literature review and synthesis of existing studies on steroid antibacterials.
  • Analysis of structural features, biosynthetic/synthetic origins, and antibacterial toxicities.
  • Examination of fungal biotransformations and catabolic pathways in the human host.

Main Results:

  • Identified steroid antibacterials from fungal origins, synthetic compounds, and approved drugs.
  • Fusidane steroids of fungal origin exhibit low minimum inhibitory concentrations (MICs) against Gram-positive and Gram-negative bacteria.
  • Fusidic acid is the sole currently prescribed steroid antibacterial, despite numerous steroids showing antibacterial activity.

Conclusions:

  • Steroids, particularly fusidane derivatives, possess significant potential as future antibacterial agents.
  • Understanding bacterial interactions with steroids and host metabolism is crucial for development.
  • Biotechnological approaches using fungi offer a promising avenue for producing novel antibacterial steroids.