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Intrapericardial Triamcinolone Instillation for Recurrent Pericardial Effusion in Pediatric Patients: A Review of

Abhiram Reddy1, Daniel Peck1, Daniel Cortez2

  • 1Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, 2450 Riverside Ave, Academic Office Building (AOB), 4th floor, # AOB-407, Minneapolis, MN, 55454, USA.

Pediatric Cardiology
|May 27, 2026
PubMed

Insights

Intrapericardial triamcinolone shows promise for treating recurrent pericardial effusion in children. This study found it effective and safe as an adjunctive therapy for pediatric patients with idiopathic pericardial effusions.

Area of Science:

  • Pediatric Cardiology
  • Pharmacology
  • Medical Case Studies

Background:

  • Recurrent pericardial effusion in children lacks extensive research regarding intrapericardial triamcinolone.
  • The efficacy and safety of intrapericardial triamcinolone in pediatric patients are not well-defined.

Purpose of the Study:

  • To evaluate the efficacy, side effects, and safety of intrapericardial triamcinolone in pediatric patients with recurrent idiopathic pericardial effusions.
  • To expand the understanding of this treatment in a pediatric population.

Main Methods:

  • Retrospective case series of nine pediatric patients treated with intrapericardial triamcinolone.
  • Data collected from 2015 to 2025 at a single center.
  • Efficacy assessed via echocardiograms and symptom monitoring; side effects documented.

Main Results:

  • Five patients achieved resolution of pericardial effusion; three showed improvement.
  • One patient experienced relapse; five had transient, steroid-like side effects.
  • Two patients died due to underlying conditions, not treatment.

Conclusions:

  • Intrapericardial triamcinolone appears to be a safe and effective adjunctive treatment for pediatric recurrent idiopathic pericardial effusion.
  • Further research is warranted to fully characterize its long-term outcomes and safety profile in children.

Keywords:
Bone marrow transplantPediatricsPericardiocentesisRecurrent pericardial effusionTriamcinolone

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