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Polyphenol-Metal Mediated Mitochondrial-Targeted Injectable Hydrogel Promotes Diabetic Wound Healing.

Xiangcun Shang1, Yan Wang1, Wenhuan Huang1

  • 1School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, P. R. China.

Advanced Healthcare Materials
|May 28, 2026
PubMed
Summary

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This summary is machine-generated.

This study presents a novel hydrogel dressing that effectively treats diabetic wounds by reducing oxidative stress, inflammation, and mitochondrial dysfunction. The advanced wound therapy promotes faster healing and tissue regeneration in diabetic patients.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Diabetic wounds pose significant challenges due to inflammation, poor vascular regeneration, and mitochondrial dysfunction, leading to delayed healing.
  • Current treatments often fail to address the multifaceted nature of diabetic wound pathology.

Purpose of the Study:

  • To develop and evaluate an injectable hydrogel dressing for treating diabetic wounds.
  • To investigate the hydrogel's ability to mitigate oxidative stress, resolve inflammation, and restore mitochondrial function.

Main Methods:

  • An injectable hydrogel was synthesized using gelatin methacrylate (GelMA), alginate methacrylate (AlgMA), and tannic acid-cobalt ion (TACo) nanoparticles.
  • Photopolymerization was used for cross-linking, and the hydrogel's properties, including pH-responsive release, were assessed.
Keywords:
diabetic wound healinginjectable hydrogelmitochondrial targetingpolyphenol‐metal nanoparticles

Related Experiment Videos

  • The hydrogel's antioxidant, antibacterial, anti-inflammatory (macrophage reprogramming), and mitochondrial protective effects were evaluated.
  • In vivo efficacy was tested in a diabetic rat wound model, assessing tissue regeneration and angiogenic marker expression.

    • Main Results:

    • The hydrogel demonstrated favorable physical properties and sustained release of bioactive components.
    • It exhibited potent free radical scavenging, broad-spectrum antibacterial activity, and promoted M2 macrophage polarization.
    • TACo nanoparticles effectively targeted mitochondria, preserved membrane integrity, and reduced oxidative stress.
    • In vivo, the hydrogel significantly accelerated re-epithelialization, improved collagen structure, and enhanced CD31 and VEGF expression, promoting wound healing.

    Conclusions:

    • The developed hydrogel dressing effectively addresses key pathological features of diabetic wounds, including oxidative stress, inflammation, and mitochondrial dysfunction.
    • This advanced wound therapy shows significant potential for promoting tissue regeneration and treating refractory diabetic wounds.