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Updated: May 29, 2026
11:13
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine
Yu-Jie Jiang1,2, Xiao-Chao Hou3, Jing Tao2,4
1Medical Imaging & Radiology Center, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China.
Journal of Magnetic Resonance Imaging : JMRI
|May 28, 2026
Summary
A new cardiac MRI measure, the left atrioventricular coupling index (LACI), effectively predicts adverse outcomes in dilated cardiomyopathy (DCM). This index offers significant prognostic value beyond traditional markers for improved risk stratification.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Dilated cardiomyopathy (DCM) poses challenges for accurate risk stratification.
- Conventional markers like LVEF and LGE do not fully capture LA and LV remodeling interplay.
- Novel imaging biomarkers are needed for improved prognostic assessment in DCM.
Purpose of the Study:
- To evaluate the prognostic capability of cardiac MRI-derived LACI in DCM patients.
- To assess if LACI provides incremental prognostic value beyond established markers.
- To determine the utility of LACI as a risk stratification tool in DCM.
Main Methods:
- Retrospective analysis of 403 DCM patients from two centers.
- LACI calculated from routine cine MRI sequences (LA minimal volume/LV end-diastolic volume).
- Cox regression and reclassification analyses (NRI) to assess prognostic value.
Main Results:
- Elevated LACI (≥45.75%) was the strongest independent predictor of adverse outcomes (mortality/HF hospitalization).
- LACI-enhanced model showed robust performance in training (C-index=0.804) and validation (C-index=0.824) sets.
- Incorporating LACI significantly improved risk prediction (NRI=0.102).
Conclusions:
- LACI derived from routine cine MRI is a strong independent predictor of adverse outcomes in DCM.
- LACI offers significant incremental prognostic value beyond conventional markers.
- LACI shows potential as a practical and effective tool for DCM risk stratification.
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