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DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition
Yuzheng Zhou1, Die Hu1, Xiang Li1
1Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Analytical Chemistry for Life Science and Intelligent Detection, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China. zhouhong@qust.edu.cn.
None:
We report an APE1/dual-miRNA-triggered ternary logic gate for high-fidelity tumor imaging. Sequential activation drives cascaded amplification, eliminating false positives and enabling in vitro cancer discrimination for in situ diagnosis.
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