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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

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Updated: May 29, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
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Accelerated SPAD-Based Diffuse Optical Tomography With Data-Driven View Optimization.

Linlin Li1, Kaiqi Kuang1, Yang Lin2

  • 1School of Information Science and Technology, ShanghaiTech University, Shanghai, China.

Journal of Biophotonics
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a faster time-domain diffuse optical tomography (TD-DOT) method using fewer views. The new approach accelerates imaging for applications like brain function monitoring without losing image quality.

Keywords:
diffuse optical tomographyfunctional brain imagingimage reconstructionsingle‐photon avalanche diodesparse view

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Area of Science:

  • Biomedical Optics
  • Medical Imaging

Background:

  • Time-domain diffuse optical tomography (TD-DOT) is a non-invasive imaging technique using near-infrared light.
  • Advanced SPAD arrays improve TD-DOT data quality but increase acquisition times.

Purpose of the Study:

  • To develop a data-driven strategy to reduce the number of views in TD-DOT acquisition.
  • To accelerate TD-DOT imaging without compromising image quality for biological monitoring.

Main Methods:

  • Developed a noncontact TD-DOT system with a pulsed laser, SPAD array, and rotational stage.
  • Implemented a data-driven view-optimization strategy leveraging time-resolved measurements.
  • Validated the method using simulations and phantom experiments.

Main Results:

  • The proposed method significantly reduces the number of required views in TD-DOT.
  • Image reconstruction quality remained robust and comparable to full-view acquisition.
  • The accelerated TD-DOT demonstrated potential for monitoring dynamic biological processes.

Conclusions:

  • A novel view-optimization strategy accelerates TD-DOT imaging.
  • This technique maintains high-fidelity reconstruction, enabling efficient monitoring of biological dynamics like cerebral hemodynamics.