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Neonatal Cholestasis Presenting With Seizures Associated With Vitamin K Deficiency: A Case Report

Bipesh Kumar Shah1, Smita Paudel1

  • 1Department of Pediatrics, B.P Koirala Institute of Health Sciences, Dharan, Nepal.

Sage Open Pediatrics
|May 28, 2026
PubMed

Insights

Neonatal cholestasis can cause Vitamin K deficiency bleeding (VKDB) in infants, presenting as GI bleeding or seizures. Early recognition and treatment of VKDB are crucial for preventing severe complications.

Area of Science:

  • Pediatrics
  • Neonatology
  • Hepatology

Background:

  • Neonatal cholestasis is a rare but significant cause of Vitamin K deficiency bleeding (VKDB).
  • VKDB can manifest as gastrointestinal bleeding or, in severe instances, intracranial hemorrhage.
  • Infants with cholestasis are at risk for coagulopathy due to vitamin K malabsorption.

Keywords:
hemorrhageneonatal cholestasisseizuresvitamin K deficiency

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