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Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

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Related Experiment Video

Updated: May 29, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Decoding sialidase: physiological roles, pathological pathways, and clinical opportunities.

Rushi Li1, Yafei Liu1, Rentong Zou2

  • 1The Second Clinical Medical College of Shandong University of Medicine, Yantai, Shandong, China.

Frontiers in Cellular and Infection Microbiology
|May 28, 2026
PubMed
Summary

Sialidase dysregulation is implicated in numerous diseases, from genetic disorders to neurodegeneration. Targeting sialidase offers potential for novel diagnostics and therapeutics in precision medicine.

Keywords:
autoimmune diseasesdesialylationphysiological functionsialic acidsialidasetumor

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Related Experiment Videos

Last Updated: May 29, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
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Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
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Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Published on: November 25, 2017

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
09:04

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation

Published on: September 7, 2010

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Sialidases are enzymes crucial for cellular homeostasis.
  • Dysregulation of sialidase activity is linked to various pathological conditions.
  • Understanding sialidase's role is key to developing new disease treatments.

Purpose of the Study:

  • To review the pathological dysregulation of sialidase in diverse human diseases.
  • To explore the molecular mechanisms connecting sialidase to disease pathogenesis.
  • To assess the translational potential of sialidase as a biomarker and therapeutic target.

Main Methods:

  • Comprehensive literature review of sialidase in genetic syndromes, infections, inflammation, cancer, and neurodegeneration.
  • Analysis of molecular mechanisms underlying sialidase-associated pathology.
  • Evaluation of current challenges and future directions for clinical translation.

Main Results:

  • Sialidase dysregulation is a common feature across a spectrum of diseases.
  • Molecular insights reveal pathways from homeostasis disruption to disease.
  • Sialidase shows promise as a diagnostic biomarker and therapeutic target.

Conclusions:

  • Sialidase biology offers a roadmap for advancing disease prevention, diagnosis, and treatment.
  • Harnessing sialidase offers therapeutic opportunities at the intersection of basic and clinical science.
  • Future research should focus on overcoming translational challenges for precision medicine applications.