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Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
Published on: October 20, 2023
Decoding sialidase: physiological roles, pathological pathways, and clinical opportunities
Rushi Li1, Yafei Liu1, Rentong Zou2
1The Second Clinical Medical College of Shandong University of Medicine, Yantai, Shandong, China.
Abstract:
This review critically examines pathological dysregulation of sialidase across genetic syndromes, infectious pathogens, inflammatory/autoimmune disorders, malignant transformations, and neurodegenerative cascades, revealing molecular mechanisms that bridge physiological homeostasis to disease pathogenesis. The translational potential is emphasized through its emerging utility as a diagnostic biomarker and therapeutic target, with frank discussion of current challenges in clinical translation-including specificity hurdles, delivery systems, and biomarker validation-and future directions for precision medicine applications. By integrating mechanistic insights with translational strategies, this work provides a roadmap for harnessing sialidase biology to advance prevention, diagnosis, and treatment paradigms for diverse human diseases, offering therapeutic opportunities at the intersection of basic science and clinical innovation.
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