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Updated: May 29, 2026

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
Lactylation modification in extracellular vesicles: A key regulator of cellular communication
Yangyu Ning1,2, Zijun Qu1,2, Zehang Xie1,2
1Central Laboratory, The First Affiliated Hospital of Wannan Medical University, Wuhu 241000, China.
None:
Lactylation, a lactate-derived post-translational modification, regulates cellular metabolism and disease progression. Extracellular vesicles (EVs) mediate intercellular communication by transferring bioactive molecules. Recent evidence reveals a self-reinforcing positive feedback loop between these processes. Lactylation enhances EV biogenesis and release by modifying regulators such as Rab7A. Conversely, internalized EVs deliver lactylation-modulating cargo-including lactate dehydrogenase A (LDHA) and circular RNAs (circRNAs)-to recipient cells, thereby reprogramming glycolysis, elevating lactate levels, and further promoting protein lactylation. This review systematically summarizes the bidirectional regulatory mechanisms linking lactylation and EVs. Furthermore, it explores the therapeutic potential of targeting this interplay in disease management, particularly for comorbidities. These insights establish a theoretical foundation for developing integrated therapeutic strategies aimed at disrupting this pathological feedback circuit.
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