Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 29, 2026

Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

Assessing the degree of cortical dislamination through electrical pattern analysis.

Ana Aquiles1, Laura Pinedo1, Mirelta Regalado1

  • 1Institute of Neurobiology, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Mexico.

Iscience
|May 28, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

Disentangling crossing fibers with advanced dMRI methods reveals bundle-specific degeneration across the visual system in asymmetric glaucoma.

PloS one·2026
Same author

Multimodal age-dependent diffusion-MRI analysis of the neocortex in a rat model of cortical dysplasia.

Scientific reports·2026
Same author

Bilateral Ventral Pathways Support Phonological Awareness at Reading Onset in Spanish-Speaking Children.

Neurobiology of language (Cambridge, Mass.)·2026
Same author

Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.

PloS one·2026

Focal cortical dysplasia (FCD) causes epilepsy, but its origins are unclear. This study shows varying cortical malformation degrees impact neural dynamics, suggesting structural changes drive network dysfunction in FCD.

Area of Science:

  • Neuroscience
  • Epileptology
  • Computational Neuroscience

Background:

  • Focal cortical dysplasia (FCD) is a primary cause of drug-resistant epilepsy in children.
  • The precise mechanisms by which FCD leads to epileptogenesis are not fully understood.
  • Recent research suggests hyperexcitability may arise from areas surrounding the malformation.

Purpose of the Study:

  • To investigate the relationship between the degree of cortical malformation and neural dynamics in FCD.
  • To explore how cytoarchitectural disorganization influences network activity and excitation-inhibition balance.
  • To develop analytical tools for understanding FCD-related network dysfunction.

Main Methods:

  • Utilized the carmustine-induced animal model of FCD.
Keywords:
Biological sciencesHealth sciencesNeuroscienceTechniques in neuroscience

More Related Videos

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

  • Recorded local field potentials using multielectrode arrays during spontaneous and perturbed activity.
  • Developed and applied a novel metric to quantify spatial signal heterogeneity.

    • Main Results:

    • Neural signal structure alterations correlated with the extent and distribution of cortical abnormalities.
    • Spatial heterogeneity in signal organization was associated with changes in the excitation-inhibition balance.
    • Variability in cytoarchitectural disorganization significantly impacts neural dynamics.

    Conclusions:

    • Cytoarchitectural variability in FCD plays a crucial role in network dysfunction and epileptogenesis.
    • The findings advance the understanding of FCD's impact on brain networks.
    • The developed analytical tools may aid in pre-surgical evaluations for epilepsy patients.