Natural Compound-Loaded PLGA Nanocarriers for Infected Wound Management: A Review

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Infected wounds present challenges like persistent microbial colonization and delayed healing.
• Poly (lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer for controlled drug delivery.
• PLGA enhances natural compound stability and therapeutic efficacy for wound treatment.

Purpose of the Study:

• To review recent advances in PLGA-based formulations with natural compounds for infected wound treatment.
• To synthesize dispersed studies on PLGA-natural compound systems for wound management.
• To provide an integrated perspective on the therapeutic potential of these nanoplatforms.

Main Methods:

• Review of recent scientific literature on PLGA-based nanostructures and natural compounds for infected wounds.
• Analysis of studies detailing fabrication, synthesis, and drug release behaviors of these nanostructures.
• Examination of bacterial biofilm-targeting mechanisms and therapeutic effects.

Main Results:

• PLGA nanostructures loaded with natural compounds demonstrate antimicrobial and anti-biofilm activities.
• These formulations promote wound healing via antioxidant, anti-inflammatory effects, angiogenesis, and collagen deposition.
• PLGA systems facilitate controlled and sustained release of natural compounds, enhancing efficacy.

Conclusions:

• PLGA-based delivery systems represent a promising strategy for effective infected wound treatment.
• These nanoplatforms advance next-generation wound care therapies by addressing challenges in wound management.
• Focusing on antibiofilm mechanisms and controlled release offers a better understanding of therapeutic potential.