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Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Updated: May 29, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Next-generation sequencing: Driving a paradigm shift from pathogen detection to systems-level analysis.

Yu Peng1,2,3, Yupu Wang4, Liwen Liu1,2,3

  • 1Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Infectious Medicine
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Next-generation sequencing (NGS) offers advanced pathogen detection and tracking for infectious diseases. This technology revolutionizes understanding and managing viral pandemics and emerging threats.

Keywords:
Advanced molecular technologyInfectious diseaseNext-generation sequencingPathogenic microorganism

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Published on: April 4, 2018

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08:57

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Published on: August 29, 2025

Area of Science:

  • Molecular Biology
  • Infectious Diseases
  • Genomics

Background:

  • Advanced molecular technologies, especially next-generation sequencing (NGS), are transforming life sciences.
  • Traditional methods are often surpassed by NGS's high throughput, specificity, and sensitivity.

Purpose of the Study:

  • To comprehensively review NGS applications in infectious diseases and pathogenic microorganisms.
  • To emphasize NGS's role in pathogen detection, identification, transmission tracking, and resistance profiling.

Main Methods:

  • Literature review of NGS applications in infectious disease research.
  • Analysis of NGS's impact on pathogen surveillance and characterization.

Main Results:

  • NGS is crucial for identifying novel therapeutic targets and monitoring viral resistance.
  • NGS facilitates rapid pathogen detection, accurate identification, and tracking of interspecies transmission.
  • NGS enables comprehensive resistance profiling of pathogens.

Conclusions:

  • NGS significantly enhances the understanding and management of infectious diseases.
  • Emerging trends and challenges in NGS application require further investigation.
  • NGS technologies are pivotal in addressing viral pandemics and emerging infectious diseases.