Exploring Perceived Interactions between EQ-5D-5L and Bolt-ons Using Composite Time-Tradeoff Valuations: A...

ObjectivesThis study qualitatively explored how bolt-ons affect the perception of EQ-5D-5L core dimensions in a valuation context.MethodsSixty Indonesian adults (aged 20-67 y, 50% female) each valued 10 health states using composite time tradeoff (cTTO). States were presented in either forward (EQ-5D-5L, then with 1 bolt-on, then 2) or backward (reversed sequence) order. Participants were assigned to 1 of 3 bolt-on dyads: vision and tiredness, cognition and social relationships, or skin irritation and self-confidence. In semistructured qualitative interviews, respondents described how adding or removing bolt-ons changed the perceived importance of the 5 core dimensions. We classified these changes as related either to measurement or to valuation, with the latter further categorized as a relative or absolute shift in importance.ResultsCognition and vision generated the most shifts in perceived importance in the forward and backward groups, respectively. Regardless of ordering group, most shifts occurred between the EQ-5D-5L alone and the version with 1 bolt-on (first presented in the dyad), with significantly fewer shifts observed between the 1-bolt-on and 2-bolt-on states. In the forward group, most shifts were classified as measurement (56%) or relative preference (29%), while the reverse was true in the backward group: relative preference (53%) or measurement (31%). Absolute preference was least common across both groups.ConclusionsThis is the first study to explore how individuals reason when valuing EQ-5D-5L+bolt-on health states. Our findings suggest that interactions between dimensions are complex and may be influenced by presentation order. Further qualitative research should directly investigate absolute preferential reasoning.HighlightsNo studies have qualitatively explored how individuals value EQ-5D health states with bolt-ons. Understanding how bolt-ons influence reasoning and interact with core dimensions is crucial for informing valuation methods and modeling strategies.Our findings show that bolt-ons can alter how participants perceive the importance of EQ-5D-5L dimensions, although changes are mostly not preference driven. Participants often rely on accessible reasoning, such as conceptual associations between dimensions. Effects vary by the bolt-on used and presentation order.Interactions between bolt-ons and core dimensions complicate efforts to develop robust valuation approaches. Future qualitative studies should aim to capture preference-based reasoning, while quantitative work is needed to disentangle preferential from nonpreferential effects.