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Design and evaluation of multi-target AGEs/ALEs inhibitors for potential application in skin anti-aging
N Andre Sasaki1, Pascal Sonnet1
1AGIR, UR4294, UFR of Pharmacy, Jules Verne University of Picardie, Amiens, France.
Abstract:
The main causes of skin aging include both intrinsic and extrinsic factors such as oxidative stress triggered by reactive oxygen species (ROS), modification of collagen and elastin by reactive carbonyl species (RCS), UV exposure, lifestyle habits and environmental pollutants. Skin aging is the most visible manifestation of senescence and is unavoidable. In particular, delaying age-related changes in facial appearance is a key objective for older adults. To address this issue, naturally occurring compounds including vitamin C, vitamin E, coenzyme Q10, resveratrol, niacinamide, carnosine, retinols (vitamin A derivatives), and hyaluronic acid are commonly used in commercially available anti-aging skincare products. These compounds are considered to be ROS and RCS scavengers or powerful humectant. This article describes a new multi-targeted anti-aging compounds for skin applications, composed of two functional moieties: one that neutralizes ROS and the other scavenges RCS. These compounds exhibit potent skin anti-aging properties, as demonstrated by their rapid and efficient scavenging of RCS, an ORAC value more than twice that of Trolox, and strong transition-metal-chelating activity.
Insights
New multi-targeted compounds neutralize reactive oxygen species (ROS) and reactive carbonyl species (RCS), offering potent anti-aging effects for skin. These novel compounds effectively combat skin aging factors like oxidative stress and collagen damage.
Area of Science:
- Dermatology and Cosmetic Science
- Biochemistry
- Materials Science
Background:
- Skin aging results from intrinsic and extrinsic factors, including oxidative stress from reactive oxygen species (ROS) and collagen modification by reactive carbonyl species (RCS).
- While numerous compounds like Vitamin C and retinoids are used in anti-aging products, there's a need for multi-targeted solutions.
- Delaying visible skin aging is a significant goal for many individuals, particularly older adults.
Purpose of the Study:
- To introduce and characterize novel multi-targeted anti-aging compounds for skin applications.
- To evaluate the efficacy of these compounds in neutralizing key aging factors (ROS and RCS).
Main Methods:
- Development of compounds with dual functional moieties: one for ROS neutralization and one for RCS scavenging.
- Assessment of antioxidant capacity using ORAC (Oxygen Radical Absorbance Capacity) assay, comparing to Trolox.
- Evaluation of transition-metal-chelating activity.
Main Results:
- The new compounds demonstrated rapid and efficient scavenging of RCS.
- Achieved an ORAC value more than double that of Trolox, indicating potent antioxidant activity.
- Exhibited strong transition-metal-chelating activity, further contributing to anti-aging properties.
Conclusions:
- The developed multi-targeted compounds show significant potential for combating skin aging.
- Their dual action against ROS and RCS, coupled with high antioxidant and chelating activities, makes them promising for advanced skincare formulations.
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