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Updated: May 29, 2026
09:51
Cochlear Surface Preparation in the Adult Mouse
Published on: November 6, 2019
The ABHD10-KCMF1 Complex Mitigates Cochlear Aging by Regulating Mitochondrial Lipid Metabolism.
Lu Peng1, Xingwei Liao1, Ying Liu1
1Department of Otorhinolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Journal of Cellular Physiology
|May 28, 2026
Summary
The ABHD10 gene may protect against age-related hearing loss (presbycusis). While higher ABHD10 expression is protective, its upregulation in aging cells promotes senescence, suggesting a complex role in hearing health.
Area of Science:
- Genetics
- Otolaryngology
- Cell Biology
Background:
- Presbycusis, or age-related hearing loss, has complex causes that are not fully understood.
- Mitochondrial dysfunction is implicated in the aging process and cellular senescence.
Purpose of the Study:
- To investigate the role of mitochondria-related genes, specifically ABHD10, in presbycusis.
- To explore the regulatory mechanisms and functional impact of ABHD10 in cellular aging and hearing loss.
Main Methods:
- Mendelian randomization analysis to assess genetic associations.
- Functional validation using cell models (HEI-OC1) and aged mouse cochlear cells.
- Gene silencing, protein analysis (Western blot), reactive oxygen species measurement, mitochondrial membrane potential assessment, lipid analysis, co-immunoprecipitation, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
Main Results:
- Genetically predicted higher ABHD10 expression was associated with protection against presbycusis.
- ABHD10 was upregulated in senescent cells, promoting senescence by affecting P21 and P16 levels.
- ABHD10 silencing in senescent cells improved mitochondrial function and reduced oxidative stress.
- ABHD10 interacts with KCMF1, forming a complex involved in cellular metabolism and stress response.
Conclusions:
- ABHD10 acts as a context-dependent mitochondrial regulator.
- The ABHD10-KCMF1 axis integrates mitochondrial quality control, lipid homeostasis, and redox balance.
- ABHD10 represents a potential therapeutic target for presbycusis.
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