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Updated: May 29, 2026
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
Published on: November 28, 2018
Identification of SNPs Associated With mRNA Expression Differences of the Complement Receptor Type 1-Like Gene in
Wei Yin1, Jiachen Cheng1, Qiongyu Li1
1Shanxi Key Laboratory for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Objective:
The aim of this study is to investigate the association between single nucleotide polymorphisms (SNPs) of porcine complement receptor 1-like (CR1-like) gene and its mRNA expression.
Methods:
SNP identification, qRT-PCR absolute quantification, linkage disequilibrium analysis and dual-luciferase reporter assay were performed using 392 forty-day-old Landrace weaned piglets.
Results:
28 SNPs were identified, 4 loci were significantly correlated with CR1-like expression (p < 0.05). The c.-1372GA mutation led to the loss of GATA-1 binding site, and significantly reduced promoter transcriptional activity (< P0.01).
Conclusion:
CR1-like gene polymorphisms regulate its expression via disrupting transcription factor binding, which provides a theoretical basis for porcine disease-resistant breeding.
