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The Lipid Droplet-Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children

Claudia Vales-Villamarín1, Antje Berthold1, Martin Lacher2

  • 1Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, Leipzig, Germany.

Obesity (Silver Spring, Md.)
|May 28, 2026
PubMed

Insights

Lipid droplet-associated hydrolase (LDAH) plays a role in childhood obesity and adipose tissue inflammation. Lower LDAH expression correlates with higher BMI SDS and increased macrophage infiltration in children.

Area of Science:

  • Adipose tissue biology
  • Obesity research
  • Human genetics

Background:

  • Lipid droplet-associated hydrolase (LDAH) is a protein found in adipose tissue with an unknown function.
  • Understanding LDAH's role is crucial for addressing obesity, particularly in children.

Purpose of the Study:

  • To investigate the function of LDAH in human adipose tissue.
  • To determine the relevance of LDAH in the context of childhood obesity.

Main Methods:

  • Analysis of LDAH variant rs13385191 and gene expression in subcutaneous adipose tissue from 296 children.
  • Studying the association between LDAH and obesity/adipose tissue biology.
  • Investigating LDAH's effect on adipogenesis in SGBS preadipocytes.

Main Results:

  • Lower LDAH expression was linked to higher BMI SDS in children.
  • Reduced LDAH expression correlated with increased macrophage infiltration in adipose tissue.
  • High LDAH expression was associated with lower circulating TNFα levels.

Conclusions:

  • LDAH appears to be involved in adipose tissue inflammation.
  • LDAH may play a role in the development of obesity in children.
Abstract

Keywords:
LDAHadipocyte differentiationadipose tissue inflammationchildrenobesity

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