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Published on: January 5, 2016
Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry
Andrea Calcagno1,2, Martina Strano3,4, Riccardo Lolatto3
1Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin.
Abstract:
We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.
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