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Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

Antonio García-Hermoso1, Rodrigo Yáñez-Sepúlveda2,3, Ignacio Hormazábal-Aguayo1,4

  • 1Navarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain.

Journal of Cachexia, Sarcopenia and Muscle
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

This study establishes sex- and age-specific handgrip strength thresholds to identify elevated cardiometabolic risk (CMR) in youth. These new benchmarks aid in early screening for cardiovascular and metabolic health in children and adolescents.

Keywords:
cut‐offgrip strengthmetabolic syndromereceiver operating characteristic curves

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Area of Science:

  • Pediatric Health
  • Cardiovascular Disease Prevention
  • Musculoskeletal Health

Background:

  • Handgrip strength is a key indicator of cardiometabolic risk (CMR) in youth.
  • Evidence-based diagnostic thresholds for identifying at-risk children are limited.
  • This research addresses the need for reliable handgrip strength benchmarks.

Purpose of the Study:

  • Establish sex-specific handgrip strength thresholds normalized to body weight for children aged 8-11 years to detect elevated CMR.
  • Synthesize existing evidence through a systematic review and meta-analysis across pediatric age groups.
  • Integrate new findings with existing data to provide comprehensive diagnostic criteria.

Main Methods:

  • Analyzed cross-sectional data from 1124 Spanish children (ages 8-11) from the MOVI-2 study.
  • Associated normalized handgrip strength with a CMR index (waist circumference, triglyceride-to-HDL ratio, mean arterial pressure, fasting insulin).
  • Utilized receiver operating characteristic curves and meta-analysis to determine optimal thresholds.

Main Results:

  • MOVI-2 study thresholds: 0.38 for boys, 0.34 for girls.
  • Meta-analysis yielded thresholds: childhood (6-12 yrs) 0.30 (girls) / 0.39 (boys); adolescence (13-18 yrs) 0.36 (girls) / 0.42 (boys).
  • Highest diagnostic accuracy in adolescent girls (AUC=0.80).

Conclusions:

  • Provides clinically relevant, sex- and age-specific thresholds for normalized handgrip strength.
  • These thresholds can serve as a valuable tool for screening elevated CMR in youth.
  • Facilitates early identification and intervention for cardiometabolic risk in pediatric populations.