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CHA2DS2-VA Score Can Be Used to Predict In-Hospital Mortality in Patients with Acute Aortic Dissection

Mustafa Lutfullah Ardic1, Hazar Harbalioğlu1, Nasir Ali Tokmak1

  • 1University of Health Sciences, Adana Health Practice and Research Center Department of Cardiology Adana Turkey Department of Cardiology, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey.

Brazilian Journal of Cardiovascular Surgery
|May 28, 2026
PubMed

Insights

The CHA2DS2-VA score predicts in-hospital mortality in patients with acute aortic dissection (AAD). Higher scores indicate increased mortality risk, suggesting its use as a prognostic marker.

Area of Science:

  • Cardiology
  • Vascular Surgery

Background:

  • The CHA2DS2-VA score is established for predicting thromboembolism in atrial fibrillation.
  • Its prognostic value in cardiovascular diseases is recognized, but its impact on acute aortic dissection (AAD) mortality is unknown.

Purpose of the Study:

  • To investigate the association between the CHA2DS2-VA score and in-hospital mortality in patients diagnosed with AAD.

Main Methods:

  • A retrospective cohort study of 113 patients surgically treated for AAD.
  • CHA2DS2-VA scores were calculated for all patients.
  • In-hospital mortality was recorded and analyzed in relation to CHA2DS2-VA scores.

Main Results:

  • In-hospital mortality occurred in 27.5% of AAD patients.
  • Mortality rates increased with higher CHA2DS2-VA scores (7% for score 1 to 53% for score ≥ 4).
  • Age, CHA2DS2-VA score (OR 2.19), and hs-CRP independently predicted mortality. A CHA2DS2-VA cutoff of 3 showed 80.5% sensitivity and 78.6% specificity for mortality.

Conclusions:

  • The CHA2DS2-VA score is an independent predictor of in-hospital mortality in AAD patients.
  • This score demonstrates potential as a valuable prognostic marker for AAD management.
Abstract

Keywords:
Acute Aortic DissectionCHA2DS2-VA ScoreMortalityhs-CRP

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