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Neonatal and early infant intussusception: a 24-year retrospective review from a tertiary referral center

Caroline Rutten1,2, Adriana Koenig3, Augusto Zani4

  • 1The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. caroline.m.e.rutten@gmail.com.

Pediatric Radiology
|May 28, 2026
PubMed

Insights

Small bowel-small bowel intussusception is common in infants under 100 days and rarely needs surgery. Ileocolic intussusception is less common but safely treated with air enema, though some cases require surgery for underlying issues.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Neonatal Medicine

Background:

  • Intussusception is rare in neonates and young infants, with limited data guiding management.
  • This study addresses the scarcity of information on intussusception in this specific age group.

Purpose of the Study:

  • To characterize the clinical presentation of intussusception in infants 100 days or younger.
  • To analyze the management strategies and outcomes for intussusception in this population.
  • To differentiate between small bowel-small bowel and ileocolic intussusception in neonates and young infants.

Main Methods:

  • Retrospective review of radiology reports and patient charts for infants ≤100 days with intussusception.
  • Inclusion criteria focused on confirmed intussusception cases, excluding those with negative imaging.
  • Classification of intussusceptions into small bowel-small bowel (SB/SB), enteric tube-related SB/SB, and ileocolic types.

Main Results:

  • Out of 124 infants (median age 55 days), 76% had SB/SB intussusception, mostly incidental and rarely requiring surgery.
  • Enteric tube-related SB/SB intussusceptions (38% of SB/SB) were managed conservatively with tube adjustments, showing complete resolution.
  • Ileocolic intussusception (24%) had an 80% success rate with air enema; 13% required surgery for pathologic lead points (e.g., duplication cysts, Meckel's diverticulum).

Conclusions:

  • Small bowel-small bowel intussusceptions are the predominant type in young infants and typically do not require surgical intervention.
  • Ileocolic intussusception, while less common, is safely and effectively managed with air enema in most instances.
  • A higher proportion of pathologic lead points are identified in ileocolic intussusceptions in this age group compared to older children, necessitating careful evaluation.
Abstract

Keywords:
Acute abdomenAir enemaInfantsIntussusceptionNeonatesSonography

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