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Updated: May 29, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

Beyond multilocus barcoding: harnessing phylogenomics and genome mining for next-generation Trichoderma-based

Nehal Atta¹, Abdelmegid I Fahmi², Khalid S Abdel-Lateif¹

¹Genetics Department, Faculty of Agriculture, Menoufia University, Shibin El-Kom, Egypt.

Applied Microbiology and Biotechnology

|May 28, 2026

Summary

Modern genomic tools improve the identification and application of Trichoderma fungi for biocontrol and industrial uses. These advances enable better strain selection and the development of reliable, sustainable bio-products.

Keywords:

Trichoderma Biocontrol Biotechnology Genomics Multilocus identification Strain improvement

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Published on: October 24, 2011

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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

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GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

Published on: October 24, 2011

Area of Science:

Agricultural biotechnology
Industrial biotechnology
Fungal genomics

Background:

Trichoderma species are valuable for producing enzymes, metabolites, and biocontrol agents.
Challenges include taxonomic complexity, strain variability, and inconsistent field performance.

Purpose of the Study:

To review how molecular and genomic tools advance Trichoderma research and application.
To integrate classical taxonomy with modern biotechnology for Trichoderma.

Main Methods:

Multilocus sequence analysis and phylogenomics for accurate identification.
Comparative and pan-genomic approaches for trait prediction.
Genetic improvement strategies: mutagenesis, protoplast fusion, genome editing.

Main Results:

Enhanced species and strain identification using multilocus and genome analyses.
Genome-guided insights connect gene families to biocontrol and enzyme production.
Strain improvement strategies lead to effective biocontrol of pathogens, nematodes, and pests.

Conclusions:

Genomic tools bridge taxonomy and biotechnology in Trichoderma.
Advances facilitate the development of reliable, sustainable bio-products.
Trichoderma is positioned as a key genomics-driven biotechnological platform.