Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 31, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Tools For Building Artificial Biological Nanostructures.

Thomas S Bradford¹, Sarah Hutchings¹, Jonathon D Liston¹

¹Centre for Programmable Biological Matter, Department of Biosciences, Durham University, South Road, Durham DH1 3LE, U.K.

|May 28, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of psuedouridine modification on human tRNA.

Biochemical Society transactions·2026

Same author

How to frustrate a plant pathogen.

The Plant journal : for cell and molecular biology·2026

Same author

A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.

Science advances·2026

Same author

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters.

Nature communications·2026

Same author

Extended Plasmonic Nanostructures Templated by Tobacco Mosaic Virus Coat Protein.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same author

Copper pyrithione complexes with endoplasmic reticulum localisation showing anticancer activity <i>via</i> ROS generation.

Chemical science·2025

Same journal

Nonadiabatic Dynamics of Photoinduced Hydrogen Dissociation on Plasmonic Au Nanoparticles: How Hot Carrier Excitation Leads to Bond Breaking.

ACS nano·2026

Same journal

Dual-Enzyme-Triggered Covalent Oligomerization Reprograms Intracellular Trafficking for Chemosensitization of Melanoma.

ACS nano·2026

Same journal

Three-Dimensional Printing Ultrastrong, Ultraductile Micro/nano Silicon Oxycarbide Ceramics Derived from a Monolithic Preceramic Resin.

ACS nano·2026

Same journal

Thermoresponsive Nanoparticles Hijack Neutrophils In Vivo to In Situ Construct Biohybrids for Enhanced Cancer and Infection Therapy.

ACS nano·2026

Same journal

Observation of Possible Ferroelectric Vortices in Bismuth Square Islands.

ACS nano·2026

Same journal

Defect-Driven Surface Reconstruction in High-Entropy Antiperovskite to Generate Mott-Schottky Interface for Boosting Oxygen Evolution.

ACS nano·2026

See all related articles

This summary is machine-generated.

Researchers review tools for designing biological nanostructures and nanomachines. These engineering biology tools aid in creating artificial systems using biological molecules, overcoming design and production challenges.

Area of Science:

* Synthetic biology and bioengineering.
* Molecular engineering and nanotechnology.
* Computational biology and bioinformatics.

Background:

* Biological nanostructures and nanomachines, including viruses and enzymes, exhibit complex capabilities like replication and catalysis.
* Engineering biology aims to design and produce artificial versions of these systems using biomolecules (proteins, nucleic acids, lipids).
* Challenges in designing, predicting properties, producing, and testing these complex systems hinder progress.

Purpose of the Study:

* To review existing computational tools for designing biological molecules for nanomachinery.
* To highlight the capabilities and successful applications of current design tools.
* To discuss future tool development and associated challenges in engineering biology.

Keywords:

DNA nanotechnology DNA origami RNA origami biological nanomachines engineering biology machine learning programmable molecules protein design

More Related Videos

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Atomically Traceable Nanostructure Fabrication

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

Related Experiment Videos

Last Updated: May 31, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Atomically Traceable Nanostructure Fabrication

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

Main Methods:

* Literature review of computational tools and methodologies for designing biological molecules.
* Analysis of case studies demonstrating the application of these tools in creating nanostructures.
* Synthesis of information on current tool limitations and future research directions.

Main Results:

* Several computational tools have been developed to facilitate the design of biological molecules for nanomachines.
* These tools have shown success in applications, aiding in the creation of novel biological systems.
* Current tools face limitations in prediction accuracy and scalability.

Conclusions:

* Advanced computational tools are crucial for overcoming the complexity in designing biological nanostructures.
* Future tools are expected to offer enhanced capabilities for designing sophisticated artificial biological systems.
* Continued development is needed to address challenges in prediction, production, and testing for engineering biology.