Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serum EDN as a novel biomarker for severe eosinophilic adult asthma.

Allergologia et immunopathologia·2026

Same author

Is local anaesthetic drug allergy really common? A 10-year single-centre retrospective analysis.

Allergologia et immunopathologia·2026

Same author

Acquired angioedema due to C1 inhibitor deficiency: real-world clinical characteristics and treatment outcomes.

Frontiers in immunology·2026

Same author

Overuse of inhaled corticosteroids in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease: Observational real-life data.

Medicine·2026

Same author

Biostimulant-mediated tolerance to biotic and abiotic stresses in cotton: the roles of seaweed and arbuscular mycorrhizal fungus.

Scientific reports·2026

Same author

Integration of whey and mycorrhizal symbiosis: a sustainable biocontrol strategy against Zucchini yellow mosaic virus in squash.

Mycorrhiza·2026

Search research articles

Related Experiment Video

Updated: May 31, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

ASTHMA PHENOTYPES AND COMORBID DISEASES.

Tuba Erdogan, Fusun Yildiz, Funda Seher Ozalp Ates

International Archives of Allergy and Immunology

|May 28, 2026

Summary

This summary is machine-generated.

Asthma comorbidities like allergic rhinitis and GERD are common and vary by asthma type. Managing these conditions improves asthma control and reduces disease burden.

Related Experiment Videos

Last Updated: May 31, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Pulmonology
Internal Medicine
Clinical Research

Background:

Asthma is a complex chronic airway disease with varying phenotypes.
Comorbidities significantly impact asthma symptom burden, treatment needs, and overall control.
Understanding comorbidity distribution across asthma phenotypes is crucial for personalized management.

Purpose of the Study:

To investigate the prevalence and patterns of comorbidities in adult asthma patients.
To analyze how comorbidities differ across various asthma phenotypes, treatment steps, and control levels.
To inform individualized asthma management strategies by identifying key comorbidities.

Main Methods:

Cross-sectional analysis of 2,053 adult participants from the Turkish Asthma Action and Research (TAAR) registry.
Data extraction included demographics, asthma phenotypes, comorbidities (categorized), treatment steps, and control status.
Statistical comparisons were conducted across phenotypes, treatment steps, and control groups.

Main Results:

Frequent comorbidities included allergic rhinitis (64.2%), chronic rhinosinusitis (32.1%), and gastroesophageal reflux (GER) (26.4%).
Upper airway diseases were more common in eosinophilic, NERD, and allergic asthma. Obesity-related comorbidities were higher in obese asthma phenotype and women.
Poorly controlled asthma correlated with increased comorbidities, including GER and diabetes mellitus, with rising comorbidity numbers worsening control.

Conclusions:

Comorbidities are highly prevalent in adult asthma and differ significantly by phenotype, sex, treatment, and control status.
Upper airway disease, GER, obesity-related conditions, and metabolic disorders substantially affect asthma severity and control.
Systematic identification and management of comorbidities are essential for optimizing asthma outcomes and reducing patient burden.