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Kluyvera Infections in Humans: A Systematic Review
Sofia Maraki1, Viktoria Eirini Mavromanolaki2, Evangelia Iliaki-Giannakoudaki3
1Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece, sofiamaraki@yahoo.gr.
Summary
This study reviewed Kluyvera infections in 97 patients, finding bacteremia and UTIs common. Early detection is crucial due to antibiotic resistance, though most outcomes were favorable.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Bacteriology
Background:
- Kluyvera species, Gram-negative bacteria, can cause opportunistic human infections, especially in immunocompromised individuals.
- These bacteria are often found in the Enterobacteriaceae family and can act as reservoirs for antibiotic resistance genes.
Purpose of the Study:
- To systematically review and evaluate all published cases of human infections caused by Kluyvera species.
- To understand the epidemiology, clinical features, and microbiology of Kluyvera infections.
Main Methods:
- A systematic literature review was conducted using PubMed and Scopus databases.
- Data on epidemiology, clinical features, and microbiology of Kluyvera human infections were extracted and analyzed.
Main Results:
- Analysis of 97 patients across 73 studies revealed common infections including bacteremia, urinary tract, intra-abdominal, and soft tissue infections.
- Kluyvera ascorbata was the most frequent species identified, and significant resistance to ampicillin and early-generation cephalosporins was observed.
- While comorbidities were frequent, particularly immunosuppression, the majority of patients (89.2%) had favorable outcomes, with a 4.3% mortality rate.
Conclusions:
- Early identification of Kluyvera species is essential for effective infection control and antimicrobial stewardship.
- The prevalence of antibiotic resistance highlights the need for careful management of Kluyvera infections.
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