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Updated: May 31, 2026

Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing
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Strain-resilient intrinsically stretchable electrochemical biointerfaces.

Yadong Xu1, Xiaotian Ma1, Kexin Fan1

  • 1Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.

Science (New York, N.Y.)
|May 28, 2026
PubMed
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This summary is machine-generated.

We developed a stretchable interface for resilient electrochemical sensing (SIRES) that maintains stable performance under high strain. This breakthrough enables reliable molecular monitoring in dynamic tissues for advanced diagnostics and therapies.

Area of Science:

  • Bioelectronics
  • Materials Science
  • Electrochemical Sensing

Background:

  • Stretchable bioelectronics face challenges in maintaining electrochemical performance under strain due to material failure and signal distortion.
  • Existing technologies often suffer from cracking, delamination, and reduced signal fidelity when integrated with dynamic biological tissues.

Purpose of the Study:

  • To introduce an intrinsically stretchable interface for resilient electrochemical sensing (SIRES) that overcomes strain-induced performance degradation.
  • To enable high-fidelity electrochemical monitoring in dynamically deforming tissues for wearable and implantable applications.

Main Methods:

  • Developed SIRES using a strain-resilient conductor, an electrically tunable interlayer, and a stretchable functional coating.
  • Characterized SIRES performance under various strain levels, up to 300%, assessing resistance stability and signal fidelity.

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  • Demonstrated multiplexed molecular monitoring using voltammetric, potentiometric, and amperometric modalities.

    • Main Results:

    • SIRES maintained near-constant resistance and high-fidelity electrochemical readouts under strains up to 300%.
    • The interface demonstrated delamination-resistant properties suitable for long-term use.
    • The platform successfully enabled multiplexed molecular monitoring in dynamic tissue models.

    Conclusions:

    • SIRES offers a robust solution for strain-resilient electrochemical sensing, addressing key limitations in current stretchable bioelectronics.
    • The design principles are generalizable to other transduction mechanisms, paving the way for advanced strain-tolerant molecular sensing.
    • This technology supports the development of next-generation wearable and implantable devices for precision diagnostics and therapy.