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pH-Responsive 7,8-DHF/HZIF-8@PLGA microspheres for modulating the osteoporotic microenvironment: Osteogenesis,
Yichong He1, Qili Sun1, Ke Hu2
1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Colloids and Surfaces. B, Biointerfaces
|May 28, 2026
Summary
A novel pH-responsive drug delivery system using 7,8-dihydroxyflavone (7,8-DHF) and hollow zeolitic imidazolate framework-8 (HZIF-8) shows promise for osteoporosis treatment. This system targets osteogenesis, inflammation, and oxidative stress in the acidic bone microenvironment for enhanced bone regeneration.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Osteoporosis is characterized by impaired osteogenesis, inflammation, and oxidative stress within an acidic bone microenvironment.
- Current treatments often lack specificity and fail to address the multifactorial nature of the disease.
Purpose of the Study:
- To develop an intelligent, pH-responsive drug delivery system for targeted osteoporosis therapy.
- To integrate multiple therapeutic agents (7,8-DHF, Zn²⁺, tannic acid) within a single platform.
Main Methods:
- Fabrication of poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulating 7,8-dihydroxyflavone (7,8-DHF) and hollow zeolitic imidazolate framework-8 (HZIF-8).
- Utilized tannic acid (TA) for hollow structure construction and ROS scavenging.
- Investigated pH-triggered release kinetics and in vitro therapeutic effects on osteoblasts and macrophages.
Main Results:
- The 7,8-DHF/HZIF-8@PLGA system demonstrated sustained, pH-responsive release, accelerated under acidic conditions.
- In vitro studies showed rescue of osteoblasts from apoptosis, enhanced osteogenic activity, and M2 macrophage polarization.
- The platform effectively scavenged reactive oxygen species (ROS) and mitigated oxidative damage.
Conclusions:
- The developed multifunctional platform simultaneously addresses osteogenesis, inflammation, and redox imbalance in a microenvironment-responsive manner.
- This intelligent drug delivery system shows significant potential for precision therapy in osteoporosis and other metabolic bone diseases.
