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Updated: May 31, 2026
09:45
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
Alzheimer's disease
Alberto Serrano-Pozo1, Valentina Escott-Price2, Lea T Grinberg3
1Mass General Brigham Department of Neurology, Boston, MA, USA; Massachusetts Alzheimer's Disease Research Center, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|May 28, 2026
Summary
Recent advances in Alzheimer's disease research offer new hope for prevention and treatment. Continued momentum is crucial to combat dementia and its progression, addressing unmet needs in clinical management.
Area of Science:
- Neuroscience
- Geriatrics
- Public Health
Background:
- Alzheimer's disease (AD) is a primary cause of dementia and a leading cause of death in high-income nations.
- Significant progress has been made in understanding AD over the past decade.
Purpose of the Study:
- To summarize recent advancements in Alzheimer's disease research.
- To highlight unmet needs and priority areas for future research.
- To discuss the evolving landscape of AD clinical management.
Main Methods:
- Review of recent epidemiological studies.
- Analysis of genetic research findings.
- Evaluation of diagnostic imaging and fluid biomarker advancements.
- Assessment of current treatment and prevention strategies.
Main Results:
- The last decade has seen exponential progress in AD epidemiology, genetics, diagnostics, and therapeutics.
- A new era in clinical management of Alzheimer's disease is emerging.
- Despite progress, significant unmet needs remain in preventing and arresting AD progression.
Conclusions:
- Continued acceleration of research momentum is vital for achieving AD prevention and halting disease progression.
- Addressing unmet needs requires focused research priorities.
- The field is poised for transformative changes in managing Alzheimer's disease.
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