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Updated: May 31, 2026
09:53
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
Evaluation of Local Tolerance of Structurally Different Olaflur Compounds
Junzhuang Chang1, Shasha Wang2, Jiaqi Shan2
1Shanghai Chn-Alternative Biotechnology Co.,Ltd, Room 203, Building 5, No. 1368, Fengpao Road, Fengxian District, Shanghai, China.
Summary
This study found that three types of Olaflur, a fluoride compound, are safe for oral care products. Skin and oral mucosal irritation tests showed minimal to no adverse effects at tested concentrations.
Area of Science:
- Toxicology
- Oral Health
- Dermatology
Background:
- Fluorides are essential in preventing dental caries through oral care products.
- Limited toxicological data exists for Olaflur, a novel fluoride compound in China.
- Three Olaflur variants (cetylamine, stearylamine, oleylamine) were investigated.
Purpose of the Study:
- To evaluate the safety of three Olaflur variants for oral care applications.
- To assess the skin irritation and sensitization potential of Olaflur compounds.
- To determine the oral mucosal irritation effects of Olaflur.
Main Methods:
- Utilized reconstructed human epidermis models for skin irritation testing.
- Employed the '2 out of 3' approach for skin sensitization assessment.
- Conducted oral mucosal irritation tests using animal models.
Main Results:
- No skin irritation was observed for any Olaflur type at 0.515% and 1.97% concentrations.
- All three Olaflur compounds demonstrated no sensitization potential.
- Oral mucosal irritation tests indicated minimal to no irritation at tested concentrations.
Conclusions:
- Olaflur variants are safe for use in oral care products under recommended conditions.
- The toxicological profile supports the use of these Olaflur compounds.
- Further research may explore long-term effects and broader applications.
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