Bioactive levan polysaccharides in cosmeceutical applications: A review

Area of Science:

• Biopolymer Science
• Cosmetic Science
• Dermatology

Background:

• Levan, a β-(2,6)-linked fructose homopolysaccharide, is a multifunctional biopolymer with unique properties.
• Its high molecular weight, bioadhesion, and low viscosity enable versatile formulation in cosmetics.
• Current cosmetic applications underutilize levan despite its potential.

Purpose of the Study:

• To provide a comprehensive overview of levan for skin health applications.
• To examine levan's mechanisms of action, biological features, and translational relevance.
• To identify challenges and opportunities for levan's commercialization in skincare.

Main Methods:

• Review of physicochemical properties and biological features of levan.
• Analysis of scientific studies and patent landscape for mechanisms of action.
• In vitro and in vivo experimental evidence evaluation.

Main Results:

• Levan demonstrates moisturizing effects comparable to hyaluronic acid.
• It exhibits tyrosinase inhibitory activity for skin brightening and anti-aging benefits.
• Levan promotes collagen synthesis, wound repair, and possesses antioxidant, anti-inflammatory, and antimicrobial properties.

Conclusions:

• Levan is a promising biopolymer for advanced cosmetic and cosmeceutical formulations.
• Its safety, biodegradability, and biocompatibility support its use in skincare.
• Addressing technological limitations and clinical validation gaps is crucial for levan's market expansion.