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Updated: May 31, 2026
08:53
Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
Published on: October 2, 2017
CTDSPL2: A comprehensive review from molecular structure to clinical applications
1Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China; Center for Life Sciences, Shaoxing Institute, Zhejiang University, Shaoxing 321000, China.
Summary
C-terminal domain small phosphatase-like 2 (CTDSPL2) is a tumor suppressor involved in cell cycle and development. Its downregulation correlates with poor prognosis in cancers, highlighting its therapeutic potential.
Area of Science:
- Molecular Biology
- Biochemistry
- Oncology
Background:
- C-terminal domain small phosphatase-like 2 (CTDSPL2), also known as SCP4, is a key member of the small C-terminal domain phosphatase (SCP/CTDSP) family.
- CTDSPL2 is increasingly recognized for its roles in cell cycle regulation, development, and cancer.
Purpose of the Study:
- To systematically review the molecular characteristics, functions, and disease mechanisms of CTDSPL2.
- To explore CTDSPL2's role in transcriptional regulation, signaling pathways, and tumorigenesis.
Main Methods:
- Literature review and systematic analysis of existing research on CTDSPL2.
- Analysis of CTDSPL2's bifunctional phosphatase activity and its targets (e.g., RNA polymerase II, Smad1/5/8, Snail).
Main Results:
- CTDSPL2 acts as a bifunctional phosphatase regulating RNA polymerase II transcription and the BMP/TGF-β signaling pathway, impacting epithelial-mesenchymal transition (EMT).
- CTDSPL2 demonstrates tumor-suppressive functions in various cancers, with its reduced expression linked to adverse patient outcomes.
- CTDSPL2 is implicated in erythrocyte differentiation, metabolic reprogramming, and epigenetic regulation.
Conclusions:
- CTDSPL2 possesses diverse biological functions, including tumor suppression and regulation of key cellular processes.
- Understanding CTDSPL2's multifaceted roles provides a basis for developing targeted cancer therapies.
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