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Updated: May 31, 2026
07:39
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
[Research progress on cellular senescence and liver diseases].
Summary
Cellular senescence, a state of cell cycle arrest, contributes to chronic liver diseases via its secretory phenotype. Senolytic drugs offer potential therapeutic strategies for liver conditions.
Area of Science:
- Cellular and Molecular Biology
- Hepatology
- Immunology
Background:
- Cellular senescence is a key factor in aging and disease, characterized by irreversible cell cycle arrest.
- The senescence-associated secretory phenotype (SASP) secretes factors that impact tissue homeostasis and disease progression.
- Chronic liver diseases are linked to liver cell senescence and SASP, affecting homeostasis and disease outcomes.
Purpose of the Study:
- To outline cellular senescence phenotypes and signaling pathways.
- To review senescence in various liver cell types and SASP in different liver diseases.
- To discuss the dual role of senescence and explore therapeutic interventions.
Main Methods:
- Literature review and synthesis of research on cellular senescence in liver disease.
- Analysis of signaling pathways and phenotypes associated with senescence and SASP.
- Evaluation of current and potential therapeutic strategies, including senolytics.
Main Results:
- Cellular senescence and SASP are implicated in metabolic-associated fatty liver disease, viral hepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma.
- Senescence exhibits dual roles, acting as both a protective and detrimental factor depending on context.
- Senolytic drugs, alone or in combination therapies, show promise for treating liver diseases.
Conclusions:
- Cellular senescence and SASP are critical in liver disease pathogenesis and progression.
- Targeting senescent cells with senolytic drugs presents a promising therapeutic avenue.
- Further research is needed to establish unified evaluation systems and biomarkers for senescence in liver disease.
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