Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated Unilateral Posterior Sacroiliac Dislocation With an Intact Anterior Pelvic Ring: Case Report of an Unusual Injury Pattern.

Case reports in orthopedics·2026
Same author

Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer.

Nature communications·2026
Same author

<i>Staphylococcus aureus</i> inhibits the NLRP3 inflammasome in macrophages to varying degrees during early and late stages of infection.

Infection and immunity·2026
Same author

Redo ascending aorta and total arch replacement in patient with Wiskott-Aldrich syndrome: A case report.

Perfusion·2026
Same author

Management of acute metabolic decompensation in maple syrup urine disease: guidance based on international clinical practice.

Orphanet journal of rare diseases·2026
Same author

Tibiotalocalcaneal arthrodesis for failed osteosynthesis of the ankle joint using a retrograde femoral intramedullary nail: a retrospective observational study.

Indian journal of orthopaedics·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026
Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
Same journal

Integrating sexual health into care for patients with cancer and chronic illness.

Nature reviews. Disease primers·2026
Same journal

Chronic graft-versus-host disease.

Nature reviews. Disease primers·2026
See all related articles
  1. Home
  3. Osteomyelitis.
  1. Home
  3. Osteomyelitis.

Related Experiment Videos

Osteomyelitis.

Sandra R Arnold1, Vincenzo Giordano2, William T Obremskey3

  • 1Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Nature Reviews. Disease Primers
|May 28, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Osteomyelitis, a severe bone inflammation often caused by bacteria, presents diagnostic and treatment challenges. Further research and multidisciplinary care are crucial for improving patient outcomes and managing complications.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Microbiology

Background:

  • Osteomyelitis is a severe bone inflammation, primarily caused by bacterial infections, affecting diverse age groups and health statuses.
  • Pathogenesis involves haematogenous spread, contiguous infection extension, or direct inoculation, with pathogens exhibiting biofilm formation and immune evasion.
  • Current diagnostic and therapeutic approaches face limitations, including unreliable biomarkers and antimicrobial resistance, leading to treatment failures and complications.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and treatment of osteomyelitis.
  • To highlight challenges in managing osteomyelitis and identify areas for future research and clinical improvement.

Main Methods:

  • Literature review of osteomyelitis pathogenesis, diagnosis, and treatment.
  • Analysis of common microbial virulence factors and host-pathogen interactions.
  • Discussion of current clinical management strategies and their limitations.

    • Main Results:

    • Bacterial pathogens causing osteomyelitis share traits like biofilm formation and immunoevasive capabilities.
    • Diagnostic and prognostic tools for osteomyelitis remain inadequate, complicating acute versus chronic infection differentiation.
    • Treatment recalcitrance and high complication rates persist despite prolonged antimicrobial therapies.

    Conclusions:

    • Effective osteomyelitis management necessitates a multidisciplinary approach integrating clinical care and research.
    • Advancements in understanding disease mechanisms are vital for developing novel diagnostic and therapeutic strategies.
    • Sustained investment in research is essential for mitigating osteomyelitis complications and improving patient prognosis.