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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
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Targeting claudins in cancer.

Yuki Niwa1, Shunsuke Matsushita1, Izuma Nakayama2

  • 1Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka, Japan.

Nature Reviews. Drug Discovery
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Claudins are key regulators of epithelial function and tight junctions. Targeting claudins, like CLDN-18.2 with zolbetuximab for gastric cancer, offers promising new avenues for cancer therapy.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Epithelial-derived malignancies represent the majority of human tumors, posing significant treatment challenges due to heterogeneity, metastasis, and therapy resistance.
  • Claudins, a family of tetra-transmembrane proteins, are crucial regulators of epithelial function and integral components of tight junctions, controlling barrier integrity and cellular organization.

Purpose of the Study:

  • To review the evolving landscape of claudin-targeting therapeutics in cancer treatment.
  • To examine key advances, emerging challenges, and future prospects in exploiting claudins as therapeutic targets.

Main Methods:

  • Review of scientific literature focusing on claudin family proteins in epithelial biology and cancer.
  • Analysis of clinical studies and therapeutic developments targeting claudins, including antibody-based therapies.

Main Results:

  • Claudin expression is frequently dysregulated in various cancers, indicating their potential as therapeutic targets.
  • The development of zolbetuximab, a CLDN-18.2-targeted antibody, represents a significant advancement, recently approved for gastric cancer treatment.
  • Targeting claudins holds promise for expanding treatment options for various cancers.

Conclusions:

  • Claudin-targeting therapeutics represent a promising frontier in oncology.
  • The success of zolbetuximab highlights the therapeutic potential of targeting specific claudins.
  • Continued research into claudin biology and targeted therapies is crucial for advancing cancer treatment strategies.