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A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
Published on: April 12, 2016
Artificial intelligence for gait and balance in neurological disorders: a scoping review of clinical applications and
C Pegorini1, D Cattaneo2,3, M Meotti1
1IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148, Milan, Italy.
Background:
Artificial intelligence (AI) has rapidly emerged within healthcare systems and neurological rehabilitation with the potential to revolutionize clinical decision-making and therapeutic strategies. However, a comprehensive understanding of how AI is currently applied to gait and balance rehabilitation in stroke, Parkinson's disease (PD), and multiple sclerosis (MS) is still lacking.
Objective:
To map the current use of AI in neurological rehabilitation, focusing on clinical purposes, geographical distribution, and applied technologies for gait and balance rehabilitation.
Methods:
Following the PRISMA-ScR statement, we conducted a literature search through MEDLINE, Cochrane CENTRAL, EMBASE, and Google Scholar up to July 2025 to identify studies applying AI-based methods to gait and balance outcomes in adults with stroke, PD, or MS. Study characteristics, AI methods, validation strategies, clinical purpose, and motor outcomes were extracted and synthesized narratively.
Results:
Eighteen studies published from 2009 to 2025 were included. Most studies were conducted in Asia (50%) and involved people with stroke (77.8%). AI was predominantly used for prognostic purposes (72.22%), such as predicting falls, gait recovery, or treatment response and diagnostic applications (33.3%). Machine learning was the most common approach (88.9%) with Random Forest, Support Vector Machine, logistic regression, and eXtreme Gradient Boosting being the most frequently applied algorithms. None of the included studies performed prospective or external validation on independent datasets.
Conclusions:
This scoping review provides a comprehensive overview of current AI applications, highlighting promising but still immature approaches in the neurological rehabilitation of gait and balance. However, substantial methodological limitations remain major barriers to clinical translation.
