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Female sexual dysfunction in type 1 diabetes: a systematic review and meta-analysis
Mainak Banerjee1,2, Indira Maisnam3, Pradip Mukhopadhyay3
1Department of Endocrinology, R N Tagore Hospital, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India.
Endocrine
|May 28, 2026
Summary
Female sexual dysfunction (FSD) affects about one-third of women with type 1 diabetes mellitus (T1DM). This condition is more common in T1DM than type 2 diabetes (T2DM), often linked to longer diabetes duration.
Area of Science:
- Endocrinology
- Reproductive Health
- Diabetes Mellitus Research
Background:
- Female sexual dysfunction (FSD) is an under-recognized complication in type 1 diabetes mellitus (T1DM).
- It significantly impacts women's quality of life and psychological well-being.
- FSD in T1DM is underrepresented in major diabetes guidelines.
Purpose of the Study:
- To determine the prevalence of FSD in women with T1DM.
- To compare the risk of FSD in T1DM versus control groups and type 2 diabetes (T2DM).
- To investigate factors influencing FSD in T1DM.
Main Methods:
- A systematic literature search was conducted across PubMed/MEDLINE, Embase, Scopus, and Web of Science.
- Cross-sectional and cohort studies including T1DM participants were analyzed.
- Data on FSD prevalence, risk ratios, and influencing variables were extracted.
Main Results:
- Pooled analysis of 18 studies revealed an FSD prevalence of 37% in adults with T1DM.
- Women with T1DM had a 2.10 times higher risk of FSD compared to age-matched controls.
- FSD risk was higher in T1DM than T2DM, influenced by diabetes duration, depression, and glycemic control.
Conclusions:
- FSD is highly prevalent in women with T1DM, affecting approximately one-third.
- The increased risk in T1DM compared to T2DM is likely associated with earlier onset and longer disease duration.
- Comprehensive care addressing physiological and psychological aspects is crucial for improving sexual health in women with T1DM.
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