Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative detection of respiratory pathogens in pediatric and adult patients using a multiplex panel.

Medicine·2026
Same author

Designing an mHealth App for Defecatory Function Rehabilitation of Post-Surgical Colorectal Cancer Survivors.

Journal of healthcare informatics research·2026
Same author

Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems.

Chemical communications (Cambridge, England)·2026
Same author

Cross-national comparison of depression and risk of diabetes in South Korea and the US: a nationwide representative comparative study.

Psychiatry research·2026
Same author

Self-Powered Flexible Triboelectric-Gated Ion-Gel Transistor for Neuromorphic Tactile Sensing and Human Activity Recognition.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Sialic acid-guided spatiotemporal hydrogel therapy for liver cancer.

Materials today. Bio·2026

Related Experiment Video

Updated: May 31, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Polymerized Polyphenol-Decorated Cationic Hydroxyethylcellulose Nanocomplexes for Enhanced Breast Cancer Cell Killing

Seoyeon Park1, Tae-Il Kim1,2

  • 1Department of Agriculture, Forestry and Bioresources, College of Agriculture and Life Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

Biomacromolecules
|May 28, 2026
PubMed
Summary

New nanocomplexes deliver epigallocatechin gallate (EG), doxorubicin (Dox), and Bcl-2 siRNA to target breast cancer. These complexes show enhanced uptake and potent anticancer effects, even in drug-resistant cells.

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Related Experiment Videos

Last Updated: May 31, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Breast cancer remains a leading cause of death, necessitating novel therapeutic strategies.
  • Drug and gene delivery systems face challenges in stability, targeting, and overcoming drug resistance.
  • Epigallocatechin gallate (EG) possesses anticancer properties but requires effective delivery mechanisms.

Purpose of the Study:

  • To develop multifunctional nanocomplexes for codelivering epigallocatechin gallate (EG), doxorubicin (Dox), and Bcl-2 siRNA.
  • To enhance breast cancer targeting and therapeutic efficacy using cationic hydroxyethyl cellulose (HEC).
  • To investigate the potential of these nanocomplexes in overcoming doxorubicin resistance.

Main Methods:

  • Synthesis of pPBA-EG polymer by grafting EG-phenylboronic acid (PBA) onto a pMVMA backbone.
  • Combination with polyethylenimine 2k-modified hydroxyethyl cellulose (HECP2k) for drug/gene encapsulation.
  • Characterization of nanocomplex size, charge, and nucleic acid condensation.
  • Evaluation of cellular uptake, transfection efficiency, and anticancer effects in MDA-MB-231 cells.

Main Results:

  • Developed pPBA-EG/HECP2k@Dox/siRNA nanocomplexes with optimal nanoscale properties and positive surface charge.
  • Demonstrated enhanced cellular uptake in MDA-MB-231 cells via sialic acid interactions.
  • Achieved significant anticancer effects, including in doxorubicin-resistant cells.
  • Observed significant Bcl-2 downregulation and FAS upregulation, confirming apoptosis induction.

Conclusions:

  • The developed nanocomplexes show promise for targeted breast cancer therapy.
  • Codelivery of EG, Dox, and Bcl-2 siRNA via pPBA-EG/HECP2k enhances therapeutic outcomes.
  • This strategy is particularly effective against sialic acid-overexpressing breast cancers.