Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is correction for gradient nonlinearity necessary in a brain diffusion tensor MRI clinical study?

PloS one·2026
Same author

Choroid plexus calcification detection using quantitative susceptibility mapping MRI.

medRxiv : the preprint server for health sciences·2026
Same author

Publisher Correction: White matter micro- and macrostructure brain charts for the human lifespan.

Nature·2026
Same author

Hematopoietic Stem Cell Transplant and Brain Volume Changes in Adults With Sickle Cell Disease.

Neurology·2026
Same author

White matter micro- and macrostructure brain charts for the human lifespan.

Nature·2026
Same author

Quantitative imaging of iron dysregulation in multiple system atrophy.

NeuroImage·2026

Related Experiment Video

Updated: May 31, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Cerebral Blood Transit in Sickle Cell Anemia.

Wesley T Richerson1, Megan A Aumann1, Alexander K Song1

  • 1Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Journal of Magnetic Resonance Imaging : JMRI
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

Sickle cell anemia patients exhibit increased venous blood volume and faster venous arrival time (VAT). These blood transit differences suggest complex vascular kinetics not solely tied to anemia severity.

Keywords:
arterial spin labelingarterial transit timebolus arrival timecapillary shuntingcerebral hemodynamicssickle cell anemia

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: May 31, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Hematology

Background:

  • Sickle cell anemia (SCA) involves increased cerebral blood flow due to reduced arterial oxygen content.
  • This can lead to venous hyperintensities on ASL MRI, potentially indicating faster capillary transit, altered OEF, and stroke risk.

Purpose of the Study:

  • Implement multi-delay ASL to quantify AAT, ATT, and VAT in SCA patients.
  • Investigate if these parameters are reduced in SCA and correlate with disease severity.

Main Methods:

  • Prospective, cross-sectional study of 40 SCA patients and 24 controls.
  • Utilized multi-delay PASL MRI to measure AAT, gray matter ATT, VAT, and venous blood volume.
  • Assessed OEF, infarcts, and vasculopathy via imaging and radiological review.

Main Results:

  • SCA patients showed significantly increased venous labeled blood volume and reduced VAT compared to controls.
  • AAT and gray matter ATT, but not VAT, correlated with hemoglobin levels.
  • No significant relationships were found between AAT, ATT, VAT, and OEF or prior infarcts.

Conclusions:

  • SCA patients demonstrate elevated venous blood volume and shorter VAT.
  • Differential relationships between blood transit and hemoglobin across vascular compartments suggest complex venous blood kinetics in SCA.