Related Experiment Video
Updated: May 31, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Digital Cognitive Behavioral Treatment of Insomnia in Youth: Protocol for an RCT Examining Feasibility,
Christina S McCrae1, Melanie A Stearns1, Micah O Mazurek2
1Sleep and Health Innovations in Neurobehavioral (SHINE) Science Center, College of Nursing, University of South Florida, Tampa, FL, USA.
Insights
This study will be the first to test a digital Cognitive Behavioral Treatment for Insomnia (dCBTi) in children. The trial will assess if dCBTi improves sleep and daytime functioning for children and their caregivers.
Area of Science:
- Pediatric Sleep Medicine
- Behavioral Health
- Digital Therapeutics
Background:
- Chronic insomnia affects up to 20% of children, leading to impaired academic performance and behavioral issues.
- It also impacts caregivers, causing stress and fatigue.
- Current treatments like Cognitive Behavioral Treatment for Insomnia (CBTi) are effective but lack accessibility.
Purpose of the Study:
- To investigate the efficacy of a moderated digital CBTi (dCBTi) for school-aged children with chronic insomnia.
- To evaluate the impact of dCBTi on sleep quality, daytime functioning, and quality of life in children and their caregivers.
- To address the gap in research regarding dCBTi randomized controlled trials (RCTs) in pediatric populations.
Main Methods:
- A randomized controlled trial involving 40 child-caregiver dyads aged 6-12 with insomnia.
- Participants will be randomized to immediate dCBTi or a waitlist control group.
- Assessments include objective/subjective sleep measures, daytime functioning, quality of life, and physiological arousal at baseline, post-treatment, and 1- and 3-month follow-ups.
Main Results:
- This section will report findings after data collection and analysis, comparing outcomes between the dCBTi and waitlist control groups.
- Results will detail improvements in child and caregiver sleep, mood, executive functioning, and stress levels.
- Physiological arousal measures, such as heart rate variability, will also be analyzed.
Conclusions:
- Digital CBTi (dCBTi) holds promise for increasing accessibility to effective insomnia treatment for children.
- This trial's findings will provide crucial evidence on the efficacy of dCBTi in a pediatric population.
- Successful implementation of dCBTi could significantly improve sleep and well-being for children and their families.
Introduction:
Chronic insomnia is associated with negative effects for children (impaired academic performance, mood and behavioral dysregulation) and their caregivers (poor sleep, stress, fatigue). Chronic insomnia is also common (up to 20% of children, 50-80% in the context of comorbidities), but underdiagnosed/treated in pediatric primary care (<10% treated). Cognitive behavioral treatment for insomnia (CBTi) is the recommended "first-line" treatment for insomnia and systematic reviews and meta-analyses provide evidence of its short-term efficacy and safety in children with chronic insomnia. Unfortunately, in-person CBTi is not widely available due to a lack of and limited access to behavioral providers. Digital forms of CBTi (dCBTi) have shown promise to improve sleep and secondary outcomes in children and have the potential to rapidly increase treatment accessibility and feasibility. However, while randomized controlled trials (RCTs) of dCBTi in adolescents and adults exist, these are lacking in children. This trial will be the first to investigate the impact of a moderated dCBTi on sleep and associated outcomes of school-aged children and their caregivers compared to a waitlist control.
Methods & Analysis:
Dyads of caregivers and children (N = 40) 6-12 years of age with insomnia will be recruited from pediatric clinics, social media, and community outreach in Tampa, FL, Gainesville, FL, Columbia, MO, Charlotteville, VA, Boston, MA, and surrounding areas. Participants will be randomized to immediate dCBTi (LAMBISM) or dCBTi a month later (waitlist control). Participants will be assessed at baseline, post-treatment, 1 and 3-month follow-ups. Child assessments include objective/subjective sleep measures, daytime functioning (mood, executive functioning), quality of life (QOL), and physiological arousal (heart rate variability). Caregiver assessments include: objective/subjective sleep measures, daytime functioning (anxiety, depression, fatigue), physiological arousal, and caregiver stress.
Ethics & Dissemination:
Ethics approval was obtained in February 2025 from the University of South Florida. All data are expected to be collected by Spring 2027. Full trial results are planned to be published in 2027. Secondary analyses of baseline data will be subsequently published.
Clinical Trial Registration Number:
NCT07091149.
Related Concept Videos
Management of Insomnia
Insomnia
Multiple factors contribute...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
