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Related Experiment Video

Updated: May 31, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Published on: March 29, 2019

Metabolic Profiling Reveals Insights Into Bladder Cancer Pathogenesis and Recurrence.

Hüseyin Saygın1, Serkan Bolat2, Demet Kablan2

  • 1Department of Urology, Sivas Cumhuriyet University, Sivas, Turkey, cumhuriyet.edu.tr.

Advances in Urology
|May 29, 2026
PubMed
Summary

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This summary is machine-generated.

Bladder cancer patients show altered urinary metabolites, including lower 11-hydroxyandrosterone, compared to healthy individuals. This steroid hormone is further reduced in recurrent bladder cancer, suggesting its role in disease progression.

Area of Science:

  • Urology
  • Metabolomics
  • Oncology

Background:

  • Bladder cancer pathogenesis involves abnormal cell proliferation, with underlying molecular mechanisms requiring further elucidation.
  • Understanding metabolic alterations is crucial for identifying biomarkers of bladder cancer progression and recurrence.

Purpose of the Study:

  • To identify distinct urinary metabolic profiles in bladder cancer patients versus healthy controls.
  • To investigate metabolic differences between bladder cancer patients with and without recurrence.
  • To explore the roles of steroid hormones and arachidonic acid metabolism in bladder cancer.

Main Methods:

  • Urinary metabolic profiling of 102 participants (82 bladder cancer patients, 20 healthy controls) using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF/MS).
Keywords:
(±)12-HETEPGE2arachidonic acidbladder cancermetabolomicssteroid hormones

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  • Data analysis and metabolite identification utilizing Mass Profiler Professional and the XCMS online platform.
  • Categorization of bladder cancer patients into recurrent (29) and non-recurrent (41) groups based on clinical findings.

    • Main Results:

    • Bladder cancer patients exhibited significantly altered urinary metabolite levels compared to healthy controls.
    • Key differences included downregulation of 11-hydroxyandrosterone and prostaglandin E2 (PGE2), and upregulation of (±)12-hydroxyeicosatetraenoic acid ([±]12-HETE), 5α-dihydrodeoxycorticosterone, and 21-hydroxypregnenolone.
    • 11-hydroxyandrosterone was significantly lower in patients with recurrent bladder cancer than in those without recurrence, with (±)12-HETE and PGE2 showing high diagnostic potential.

    Conclusions:

    • Urinary metabolic profiling reveals distinct signatures associated with bladder cancer and its recurrence.
    • Alterations in steroid hormone and arachidonic acid metabolism are implicated in bladder cancer pathogenesis.
    • These findings may pave the way for novel diagnostic and therapeutic strategies for bladder cancer.