Molecular and Genetic Aspects of Lipid Metabolism Disorders and Potential Targets for Gene Therapy

Area of Science:

• Biochemistry
• Genetics
• Cardiology

Background:

• Cardiovascular diseases (CVDs) are a leading cause of global mortality and disability.
• Impaired lipid metabolism, both primary (genetic) and secondary (lifestyle-induced), is a significant contributor to CVDs.
• Understanding lipid metabolism pathways is crucial for developing effective therapeutic interventions.

Purpose of the Study:

• To review potential therapeutic targets for lipid metabolism disorders.
• To summarize current gene therapy approaches for treating lipid metabolism-related diseases.
• To explore the future potential of gene therapy in managing cardiovascular disease.

Main Methods:

• Literature review of studies on lipid metabolism, cardiovascular disease, and gene therapy.
• Analysis of genetic factors and lifestyle influences on lipid metabolism.
• Examination of existing and emerging gene therapy strategies.

Main Results:

• Identification of key genes and pathways involved in lipid metabolism disorders.
• Overview of various gene therapy techniques applicable to metabolic diseases.
• Discussion of the potential of gene therapy to address both primary and secondary lipid disorders.

Conclusions:

• Targeting lipid metabolism offers a viable strategy for CVD prevention and treatment.
• Gene therapy presents a promising frontier for managing complex lipid metabolism disorders.
• Further research and technological advancements in gene therapy are expected to expand treatment options for cardiovascular health.